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But bariatric surgery has a pronounced effect in shifting patients’ preferences away from high-fat foods. Scientists just don’t know why. The natural version of the GDF15 protein breaks down quickly in the blood. To be an effective weight-loss aid, it would need more staying power. The Amgen researchers accomplished this by fusing the protein with other agents that would not break down so quickly. The two engineered versions of GDF15 remain biologically active in the blood for longer. In the brains of the lab animals that received the treatment, the study authors detected activation in a population of brain-stem cells that transmits complex signals between the brain and gut. In obese people, those signals — which urge us to eat when we’re hungry and to stop once we’ve eaten — become faulty, causing us to overeat and gain weight. Bariatric surgery appears to correct those signals. So the suggestion that GDF15 might do the same is an exciting indication that a piece of bariatric surgery’s magic might be bottled up in a pill. “This is a new system” involved in the regulation of appetite, said Dr.

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